Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: cytochrome P-450KORZEKWA, K. R; TRAGER, W. F; GILLETTE, J. R et al.Biochemistry (Easton). 1989, Vol 28, Num 23, pp 9012-9018, issn 0006-2960Article

Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylationKORZEKWA, K. R; SWINNEY, D. C; TRAGER, W. F et al.Biochemistry (Easton). 1989, Vol 28, Num 23, pp 9019-9027, issn 0006-2960Article

Theoretical studies on cytochrome P-450 mediated hydroxylation : a predictive model for hydrogen atom abstractionsKORZEKWA, K. R; JONES, J. P; GILLETTE, J. R et al.Journal of the American Chemical Society. 1990, Vol 112, Num 19, pp 7042-7046, issn 0002-7863Article

A site-directed mutagenesis study of human placental aromataseDUJIN ZHOU; KORZEKWA, K. R; POULOS, T et al.The Journal of biological chemistry (Print). 1992, Vol 267, Num 2, pp 762-768, issn 0021-9258Article

cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirusBUTERS, J. T. M; KORZEKWA, K. R; KUNZE, K. L et al.Drug metabolism and disposition. 1994, Vol 22, Num 5, pp 688-692, issn 0090-9556Article

Chimeric cDNA expression and site directed mutagenesis studies of cytochrome P450s CYP2A1 and CYP2A2HANIOKA, N; GONZALEZ, F. J; LINDBERG, N. A et al.Journal of steroid biochemistry and molecular biology. 1992, Vol 43, Num 8, pp 1037-1043, issn 0960-0760Conference Paper

Theoretical studies on the mechanism of conversion of androgens to estrogens by aromataseKORZEKWA, K. R; TRAGER, W. F; SMITH, S. J et al.Biochemistry (Easton). 1991, Vol 30, Num 25, pp 6155-6162, issn 0006-2960Article

The effects of diabetes on placental aromatase activityMCROBIE, D. J; KORZEKWA, K. R; GLOVER, D. D et al.Journal of steroid biochemistry and molecular biology. 1997, Vol 63, Num 1-3, pp 147-153, issn 0960-0760Article

Selectively deuterated warfarin : Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450DARBYSHIRE, J. F; IYER, K. R; GROGAN, J et al.Drug metabolism and disposition. 1996, Vol 24, Num 9, pp 1038-1045, issn 0090-9556Article

Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4GELBOIN, H. V; KRAUSZ, K. W; GOLDFARB, I et al.Biochemical pharmacology. 1995, Vol 50, Num 11, pp 1841-1850, issn 0006-2952Article

Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effectsJONES, J. P; KORZEKWA, K. R; RETTIE, A. E et al.Journal of the American Chemical Society. 1986, Vol 108, Num 22, pp 7074-7078, issn 0002-7863Article

Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives : enzyme specificity, interindividual distribution and metabolic contribution in human liverMAGANG SHOU; MARTINET, M; KORZEKWA, K. R et al.Pharmacogenetics (London). 1998, Vol 8, Num 5, pp 391-401, issn 0960-314XArticle

Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estroneSHOU, M; KORZEKWA, K. R; BROOKS, E. N et al.Carcinogenesis (New York. Print). 1997, Vol 18, Num 1, pp 207-214, issn 0143-3334Article

Isotope effect studies on the cytochrome P450 enzymesKORZEKWA, K. R; GILLETTE, J. R; TRAGER, W. F et al.Drug metabolism reviews (Softcover ed.). 1995, Vol 27, Num 1-2, pp 45-59, issn 0360-2532Conference Paper

Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450DUJIN ZHOU; CAM, L. L; LAUGHTON, C. A et al.The Journal of biological chemistry (Print). 1994, Vol 269, Num 30, pp 19501-19508, issn 0021-9258Article

Selective biotransformation of taxol to 6α-hydroxytaxol by human cytochrome P450 2C8RAHMAN, A; KORZEKWA, K. R; GROGAN, J et al.Cancer research (Baltimore). 1994, Vol 54, Num 21, pp 5543-5546, issn 0008-5472Article

Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolismMAGANG SHOU; TIN LU; KRAUSZ, K. W et al.European journal of pharmacology. 2000, Vol 394, Num 2-3, pp 199-209, issn 0014-2999Article

Involvement of multiple cytochrome P450 isoforms in naproxen 0-demethylationTRACY, T. S; MARRA, C; WRIGHTON, S. A et al.European journal of clinical pharmacology. 1997, Vol 52, Num 4, pp 293-298, issn 0031-6970Article

Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)- flurbiprofenTRACY, T. S; ROSENBLUTH, B. W; WRIGHTON, S. A et al.Biochemical pharmacology. 1995, Vol 49, Num 9, pp 1269-1275, issn 0006-2952Article

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4RELLING, M. V; NEMEC, J; SCHUETZ, E. G et al.Molecular pharmacology. 1994, Vol 45, Num 2, pp 352-358, issn 0026-895XArticle

Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactionsKORZEKWA, K. R; TRAGER, W. F; MANCEWICZ, J et al.Journal of steroid biochemistry and molecular biology. 1993, Vol 44, Num 4-6, pp 367-373, issn 0960-0760Conference Paper

12α-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2SMITH, S. J; KORZEKWA, K. R; AOYAMA, T et al.Drug metabolism and disposition. 1992, Vol 20, Num 4, pp 566-571, issn 0090-9556Article

Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of Δ⁶-testosterone from testosteroneKORZEKWA, K. R; TRAGER, W. F; NAGATA, K et al.Drug metabolism and disposition. 1990, Vol 18, Num 6, pp 974-979, issn 0090-9556, 6 p.Article

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamilTRACY, T. S; KORZEKWA, K. R; GONZALEZ, F. J et al.British journal of clinical pharmacology. 1999, Vol 47, Num 5, pp 545-552, issn 0306-5251Conference Paper

Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepamYANG, T. J; MAGANG SHOU; KORZEKWA, K. R et al.Biochemical pharmacology. 1998, Vol 55, Num 6, pp 889-896, issn 0006-2952Article